Paper mill effluent is a major source of pollution generating industry discarding huge amount of intensely colored effluent. Some are rich in wood fiber and harbor good carbon source further the primary and de-inking paper mill effluent others carry effluents rich in nitrogen and phosphorus. Lack of infrastructure, technical manpower research and development facilities restrict these mills to recover the chemicals. The chemical oxygen demand of the emanating stream is quite high and floating minuscule of debris. Rapid increase of population and the increased demand for industrial establishments to meet human needs have created problems such as over exploitation of available resources, increased pollution in air and water environment hence there is a growing demand to treat the effluent with the native industrial samples isolates. ( Shanthi J1, Krubakaran CTB2 and Balagurunathan R1 1Department of Microbiology, Periyar University, Salem -636 011, India 2012 ). Pulp and paper industrial effluent is rich in recalcitrant compounds and causes pollution. For the treatment of such compounds activated sludge process is frequently used in which F/M ratio is kept low. This treatment results in effective biochemical oxygen demand removal but other waste water parameters are not reduced effectively due to lack of dissolve oxygen. In the present study sequential batch reactor was used for the removal of pollutants from the waste water of pulp and paper mill by using bacterial consortium (Klebsiella sp., Alcaligens sp. and Cronobacter sp.). The aim of present research is to identify the influences of F/M ratio and dissolved oxygen concentration on the microorganism’s growth and pollutant removal. The process of bioremediation was optimized by Taguchi approach. Conti.............